Our group has developed multiple accurate segmentation methods during years. Our nonlinear patch-based method with error correction is one of the most accurate methods of segmentation of medial temporal lobe structures. Our method reaches 0.901 of Dice similarity with manual tracing for hippocampus which is one of the highest values reported in the literature. Medial temporal lobe atrophy and especially hippocampal atrophy has been one of the most investigated AD biomarkers.
- Zandifar, A., Fonov, V. , Coupé, P., Pruessner, J. C., & Collins, D. L. (2014). A unified assessment of fully automated hippocampus segmentation methods. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, 10(4), P86.
- Zandifar, A., Fonov, V. , Coupé, P., Pruessner, J. C., & Collins, D. L. (2015). A quantitative comparison between two manual hippocampal segmentation protocols. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, 11(7), P67-P68.
