The interpretation of magnetic resonance (MR) images of the human brain is facilitated when different data sets can be compared by visual inspection of equivalent anatomical planes. Quantitative analysis with pre-defined atlas templates often requires the initial alignment of atlas and image planes.

A completely automatic method has been developed, to register a given volumetric data set to a template. Once the data set is resampled by the transformation recovered by the algorithm, anatomical atlases can be matched to the corresponding voxels of the MRI scan. The use of a standardized stereotaxic space also allows the direct comparison, voxel-to-voxel, of two or more data sets.


  1. DL Collins, P Neelin, TM Peters and AC Evans, Automatic 3D Inter-Subject Registration of MR Volumetric Data in Standardized Talairach Space,Journal of Computer Assisted Tomography, 18(2) p192-205, 1994
  2. DL Collins, CJ Holmes, TM Peters and AC Evans, Automatic 3D model-based neuro-anatomical segmentation Human Brain Mapping, 3(3) p 190-208, 1995


Automated registration tools are included in minc-toolkit software package, see Software section for details