Histopathology and MRI studies differentiate between focal white matter lesions (FWML) and diffuse abnormal white matter (DAWM). These two categories of white matter T2-weighted (T2w) hyperintensities show different degrees of demyelination, axonal loss and immune cell density in pathology, potentially offering distinct correlations with symptoms. We have developed an automated tool to separate FWML and DAWM based on their intensity profile in T2-weighted images.

Lesion Separation Tool Script