Neurodegenerative diseases such as Alzheimer’s disease (AD) commonly coexist with cerebrovascular disease in the elderly population. Cerebral small vessel disease (SVD) is the most common vascular cause of dementia and a major contributor to mixed dementia. SVD frequently coexists with AD and can increase the cognitive and physical deficits caused by neurodegeneration. White matter hyperintensities (WMHs) are considered to be one of the major signs of SVD on MRI and are associated with neurological and cognitive symptoms and physical difficulties. We have developed automated tools for segmentation of WMHs in Alzheimer’s patients using multiple contrasts of MR images. We use these segmentations to study the effect of WMHs in AD.
WMH Segmentation Pipeline:
- Dadar, M., J. Maranzano, K. Misquitta, C. J. Anor, V. S. Fonov, M. C. Tartaglia, O. T. Carmichael, C. Decarli, D. L. Collins, and Alzheimer’s Disease Neuroimaging Initiative. “Performance comparison of 10 different classification techniques in segmenting white matter hyperintensities in aging.” NeuroImage 157 (2017): 233.
- Dadar, Mahsa, Tharick Pascoal, Sarinporn Manitsirikul, Karen Misquitta, Carmela Tartaglia, John Brietner, Pedro Rosa-Neto, Owen Carmichael, Charles DeCarli, and D. Louis Collins. “Validation of a Regression Technique for Segmentation of White Matter Hyperintensities in Alzheimer’s Disease.” IEEE Transactions on Medical Imaging (2017).
- Dadar, M., Pascoal, T. A., Manitsirikul, S., Breitner, J., Rosa-Neto, P., & Collins, D. L. (2015). Accurate automatic segmentation of white matter hyperintensities using a linear regression classifier. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, 11(7), P94-P95.
- Dadar, M., Pascoal, T. A., Manitsirikul, S., Breitner, J., Rosa-Neto, P., Carmichael, O., & Collins, D. L. (2015). Spatial distribution of white matter hyperintensities in elderly individuals. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, 11(7), P93-P94.
- Pascoal, T. A., Dadar, M., Manitsirikul, S., Breitner, J., Collins, D. L., Poirier, J., … & Rosa-Neto, P. (2015). Association between apolipoprotein ai levels and white matter hyperintensities depends on CSF tau levels in a high-risk cohort of aging cognitively normal persons: The prevent-alzheimer’s disease study. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, 11(7), P103.